Biochemical Factors Modulating Cellular Neurotoxicity of Methylmercury
نویسندگان
چکیده
منابع مشابه
Biochemical Factors Modulating Cellular Neurotoxicity of Methylmercury
Methylmercury (MeHg), an environmental toxicant primarily found in fish and seafood, poses a dilemma to both consumers and regulatory authorities, given the nutritional benefits of fish consumption versus the possible adverse neurological damage. Several studies have shown that MeHg toxicity is influenced by a number of biochemical factors, such as glutathione (GSH), fatty acids, vitamins, and ...
متن کاملRole of docosahexaenoic acid in modulating methylmercury-induced neurotoxicity.
The effect of docosahexaenoic acid (DHA) in modulating methylmercury (MeHg)-induced neurotoxicity was investigated in C6-glial and B35-neuronal cell lines. Gas chromatography measurements indicated increased DHA content in both the cell lines after 24 h supplementation. Mitochondrial activity evaluated by 3-(4, 5-dimethylthiazol-2-yl)-2, 5 diphenyltetrazolium bromide (MTT) reduction indicated t...
متن کاملMethylmercury neurotoxicity & antioxidant defenses.
Neurotoxicity induced by methylmercury (MeHg) increases the formation of reactive radicals and accelerates free radical reactions. This review summarizes recent findings in the MeHg-induced formation of free radicals and the role of oxidative stress in its neurotoxicity. Oxidative stress on CNS can produce damage by several interacting mechanisms, including mitochondrial damage with increase in...
متن کاملMechanisms of methylmercury-induced neurotoxicity.
Mercury in both organic and inorganic forms is neurotoxic. Methylmercury (MeHg) is a commonly encountered form of mercury in the environment. Early electrophysiological experiments revealed that MeHg potently affects the release of neurotransmitter from presynaptic nerve terminals. Recently, the hypothesis that these alterations may be mediated by changes in the intracellular concentration of C...
متن کاملMethylmercury exposure and developmental neurotoxicity
We are concerned that certain aspects of the systematic review on methylmercury (MeHg) exposure from seafood consumption and the risk of developmental neurotoxicity published in the Bulletin of World Health Organization could be misinterpreted.1 Specifically, the review does not address the issue of whether naturally-occurring, background levels of prenatal exposure to MeHg from maternal fish c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Toxicology
سال: 2011
ISSN: 1687-8191,1687-8205
DOI: 10.1155/2011/721987